Diaryl 2 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Sulfonylureas
Indications
- Lowering blood glucose in noninsulin dependent diabetes mellitus (NIDDM)
- Adjunct to diet and exercise
- Combination therapy with metformin or insulin
- Use in conjunction with an oral hypoglycaemic agent
Pharmacology
- Sulfonylurea antidiabetic agent
- Stimulates release of insulin from pancreatic beta cells
- Improves sensitivity of beta cells to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Enhances glucose uptake
Dosage
- Initial dose of 1 mg once daily
- Gradual dose titration based on glucose monitoring
- Usual dose range of 1 to 4 mg daily
- Timing and distribution of doses decided by physician
- Swallow with sufficient amount of liquid
- Dose adjustments based on control of diabetes, weight changes, and lifestyle
Administration
- Tablet must be swallowed with sufficient liquid
Interaction
- Potentiating drugs include ACE inhibitors, aminosalicylic acid, anabolic steroids, azapropazone, etc.
- Attenuating drugs include acetazolamide, barbiturates, calcium channel blockers, etc.
- Concomitant treatment with beta-receptor blockers, clonidine, guanethidine, or reserpine may mask hypoglycaemic symptoms
- Alcohol intake may potentiate or attenuate activity in an unpredictable fashion
Contraindications
- Insulin dependent diabetes mellitus
- Diabetic ketoacidosis
- Diabetic coma
- Hypersensitivity to Glimepiride or other sulfonylureas
- Severe hepatic dysfunction
- Severe impairment of renal function
- Dialysis patients
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy
- Changeover to insulin is necessary
- Harmful when taken during breastfeeding
Precautions & Warnings
- Increased risk of hypoglycaemia in initial weeks of treatment
- Necessitates careful monitoring
- Promptly controlled by immediate intake of carbohydrates (glucose or sugar)
Overdose Effects
- Can produce hypoglycaemia
- Mild symptoms treated aggressively with oral glucose and adjustments in drug dosage or meal patterns
- Severe reactions constitute medical emergencies requiring immediate hospitalization
- Administer concentrated (50%) glucose solution for hypoglycaemic coma
- Close monitoring for at least 24 to 48 hours
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children