Diaryl 3 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for lowering blood glucose in type II diabetes mellitus
- Concomitant use with metformin
- Combination use with insulin for lowering blood glucose
- Potential for increasing the potential for hypoglycaemia
Pharmacology
- Sulfonylurea antidiabetic agent
- Decreases blood glucose concentration
- Stimulates insulin release from pancreatic beta cells
- Improves beta cell sensitivity to glucose
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Enhances glucose uptake
Dosage
- Dosage based on desired blood sugar level
- Initial and maintenance doses determined by regular glucose monitoring
- Gradual dose titration
- Usual initial dose of 1 mg once daily
- Usual dose range in well-controlled diabetes is 1 to 4 mg daily
- Timing and distribution of doses decided by the physician
- Importance of not skipping meals after taking the drug
- Dose adjustment with changes in weight or lifestyle
Administration
- Tablet must be swallowed with sufficient amount of liquid
Interaction
- Drugs potentiating the hypoglycaemic action
- Drugs attenuating the hypoglycaemic action
- Potential interactions with insulin and other oral antidiabetic agents
- Interactions with various drug classes
Contraindications
- Not suitable for insulin dependent diabetes mellitus
- Not suitable for diabetic ketoacidosis
- Contraindicated in patients hypersensitive to glimepiride or other sulfonylureas
- Severe hepatic dysfunction
- Severe impairment of renal function
- Dialysis patients
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy
- Patients planning a pregnancy must inform their physician
- Not to be taken during breastfeeding
- Necessity for changeover to insulin
Precautions & Warnings
- Increased risk of hypoglycaemia in initial weeks of treatment
- Careful monitoring and dosage adjustment
- Prompt control of hypoglycaemia by intake of carbohydrates
Overdose Effects
- Potential for hypoglycaemia
- Treatment of mild hypoglycaemic symptoms
- Severe hypoglycaemic reactions as medical emergencies
- Hospitalization and continuous monitoring
Therapeutic Class
- Sulfonylureas
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children