Dieta 4 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for Type II diabetes mellitus
- May be used with metformin for glycaemic control
- May be used in combination with insulin
- Increases potential for hypoglycaemia when combined with insulin
Pharmacology
- Sulfonylurea antidiabetic agent
- Stimulates insulin release from pancreatic beta cells
- Improves sensitivity of beta cells to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
Dosage
- Determined by desired blood sugar level
- Lowest effective dose for desired metabolic control
- Initial dose is 1 mg once daily
- Daily dose can be increased gradually
- Usual dose range is 1 to 4 mg daily
- Timing and distribution decided by physician based on patient's lifestyle
- Dose adjustment required with changes in patient's weight or lifestyle
- No exact dosage relationship with other blood sugar lowering agents
Administration
- Tablet must be swallowed with sufficient liquid
Interaction
- Potentiates hypoglycaemic action with various drugs
- Attenuates hypoglycaemic action with certain drugs
- May mask warning symptoms of hypoglycaemic attack
- Alcohol intake may affect the activity of the medication
Contraindications
- Not suitable for insulin dependent diabetes mellitus
- Not suitable for diabetic ketoacidosis or coma
- Hypersensitivity to Glimepiride or sulfonylureas
- Severe hepatic dysfunction
- Severe impairment of renal function
- Not for dialysis patients
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy
- Changeover to insulin necessary
- Harmful if taken during breastfeeding
- Changeover to insulin or discontinuation of breastfeeding necessary
Precautions & Warnings
- Risk of increased hypoglycaemia in initial weeks of treatment
- Dosage adjustment needed if hypoglycaemia risk present
- Prompt control of hypoglycaemia with immediate intake of carbohydrates
Overdose Effects
- Overdosage can produce hypoglycaemia
- Mild symptoms treated with oral glucose and adjustments in drug dosage or meal patterns
- Severe reactions require immediate hospitalization and IV glucose injection
- Close monitoring needed for 24 to 48 hours
Therapeutic Class
- Sulfonylureas
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children