Glirid 2 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Glimepiride
Company General pharmaceuticals ltd
Also available as
Glirid 1 mg tablet

Indications

  • Adjunct to diet and exercise for lowering blood glucose in Type II diabetes
  • Use in combination with metformin for adequate glycaemic control
  • Can be used in combination with insulin for lowering blood glucose
  • Potential for hypoglycaemia when combined with insulin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Stimulates insulin release from pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Hypoglycaemic action lasts for 24 hours

Dosage

  • Initial dose of 1 mg once daily
  • Dose titration based on blood sugar monitoring
  • Usual dose range for well-controlled diabetes is 1 to 4 mg daily
  • Single daily dose before breakfast
  • Dosage adjustments based on changes in sensitivity to insulin

Administration

  • Tablet must be swallowed with sufficient liquid

Interactions

  • Interactions with various drugs that potentiate or attenuate hypoglycaemic action
  • Caution needed with ACE inhibitors, aminosalicylic acid, corticosteroids
  • Drugs like barbiturates, diuretics, and beta-blockers may weaken hypoglycaemic effects

Contraindications

  • Not suitable for insulin-dependent diabetes mellitus
  • Contraindicated in diabetic ketoacidosis
  • Hypersensitivity to Glimepiride or sulfonylureas
  • Avoid in severe hepatic dysfunction and renal impairment

Side Effects

  • Hypoglycaemia
  • Temporary visual impairment
  • Nausea, vomiting, diarrhea
  • Abdominal pain, urticaria
  • Fall in blood pressure

Pregnancy & Lactation

  • Avoid during pregnancy, switch to insulin
  • Not safe for breastfeeding women
  • Discontinue breastfeeding or switch over

Precautions & Warnings

  • Increased risk of hypoglycaemia in initial treatment
  • Dosage adjustments may be necessary
  • Prompt control of hypoglycaemia with carbohydrate intake

Overdose Effects

  • Hypoglycaemia from overdosage can occur
  • Mild symptoms can be treated with oral glucose
  • Severe reactions require immediate hospitalization

Therapeutic Class

  • Sulfonylureas

Storage Conditions

  • Store below 30°C
  • Protect from light
  • Keep out of reach of children

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