Limpet 2 mg (Tablet)

Unit Price: ৳ 7.00 (4 x 14: ৳ 392.00)
Strip Price: ৳ 98.00

Medicine Details

Category Details
Generic Glimepiride
Company Drug international ltd
Also available as
Limpet 1 mg tablet Limpet 3 mg tablet Limpet 4 mg tablet

Indications

  • Adjunct to diet and exercise to lower blood glucose in noninsulin dependent (Type II) diabetes mellitus (NIDDM)
  • Use in combination with metformin when diet, exercise, and Limpet or metformin alone do not result in adequate glycaemic control
  • Use in combination with insulin to lower blood glucose in patients whose hyperglycaemia cannot be controlled by diet and exercise
  • Potential for increased susceptibility to hypoglycaemia with combined use of Limpet and insulin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Stimulates release of insulin from functioning pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin and glucose uptake
  • Hypoglycaemic action persists for 24 hours in non-fasting diabetic patients

Dosage

  • Initial dose of 1 mg once daily
  • Gradual titration based on regular blood sugar monitoring
  • Maintenance dose range of 1 to 4 mg daily
  • Timing and distribution of doses decided by physician based on patient's current lifestyle
  • Importance of not skipping meals after taking the drug
  • Consideration for dose adjustment with changes in patient's weight or lifestyle

Administration

  • Tablet form
  • To be swallowed with sufficient amount of liquid

Interaction

  • Potentiating drugs: ACE inhibitors, aminosalicylic acid, anabolic steroids, azapropazone, etc.
  • Attenuating drugs: Acetazolamide, barbiturates, calcium channel blockers, corticosteroids, etc.
  • Masking of hypoglycaemic attack symptoms by concomitant treatment with certain drugs
  • Unpredictable effects with acute and chronic alcohol intake

Contraindications

  • Not suitable for insulin dependent (type I) diabetes mellitus
  • Not for treatment of diabetic ketoacidosis or diabetic coma
  • Hypersensitivity to Glimepiride, other sulfonylureas, other sulfonamides
  • Severe hepatic dysfunction, severe impairment of renal function, dialysis patients

Side Effects

  • Hypoglycaemia
  • Temporary visual impairment
  • Nausea, vomiting, diarrhoea, abdominal pain
  • Urticaria
  • Fall in blood pressure

Pregnancy & Lactation

  • Not to be taken during pregnancy; changeover to insulin necessary
  • Harmful effects with breast milk feeding; not to be taken by breastfeeding women

Precautions & Warnings

  • Increased risk of hypoglycaemia in initial weeks of treatment
  • Necessity for careful monitoring and potential dosage adjustment
  • Prompt control of hypoglycaemia by immediate intake of carbohydrates (glucose or sugar)

Overdose Effects

  • Hypoglycaemia with mild or severe symptoms
  • Treatment with oral glucose and adjustments in drug dosage or meal patterns
  • Severe reactions constitute medical emergencies requiring hospitalization
  • Continuous monitoring for at least 24 to 48 hours after hypoglycaemic coma

Therapeutic Class

  • Sulfonylureas

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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