Secrin 1 mg (Tablet)

Unit Price: ৳ 6.00 (6 x 10: ৳ 360.00)
Strip Price: ৳ 60.00

Medicine Details

Indications

  • Adjunct to diet and exercise to lower blood glucose in Type II diabetes mellitus
  • May be used concomitantly with metformin for glycaemic control
  • Indicated for use in combination with insulin to lower blood glucose
  • Potential for increased risk of hypoglycaemia with combined use of Secrin and insulin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Stimulates release of insulin from pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin and glucose uptake

Dosage

  • Initial dose of 1mg once daily
  • Dose titration based on regular blood sugar monitoring
  • Usual dose range is 1 to 4mg daily
  • Timing and distribution of doses decided by physician based on patient's lifestyle
  • Dose adjustment based on changes in weight or lifestyle
  • Instructions for changeover from other oral antidiabetics to Glimepiride

Administration

  • Tablet must be swallowed with sufficient amount of liquid

Interaction

  • Drugs that potentiate hypoglycaemic action of Secrin
  • Drugs that attenuate hypoglycaemic action of Secrin
  • Potential masking of hypoglycaemic warning symptoms with concomitant beta-receptor blocker, clonidine, guanethidine or reserpine use
  • Unpredictable effects of acute and chronic alcohol intake on Secrin activity

Contraindications

  • Not suitable for insulin dependent diabetes mellitus
  • Not to be used in diabetic ketoacidosis or diabetic coma
  • Hypersensitivity to Glimepiride, other sulfonylureas, or other sulfonamides
  • Severe hepatic dysfunction, severe impairment of renal function, and dialysis patients

Side Effects

  • Hypoglycaemia
  • Temporary visual impairment
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Urticaria
  • Fall in blood pressure

Pregnancy & Lactation

  • Not to be taken during pregnancy
  • Changeover to insulin is necessary during pregnancy
  • Harmful effects on breastfeeding child
  • Not to be taken by breastfeeding women

Precautions & Warnings

  • Initial weeks of treatment may increase risk of hypoglycaemia
  • Necessitates careful monitoring
  • Prompt control of hypoglycaemia by immediate intake of carbohydrates (glucose or sugar)

Overdose Effects

  • Can produce hypoglycaemia
  • Mild symptoms treated with oral glucose and adjustments in drug dosage or meal patterns
  • Severe reactions require immediate hospitalization and IV glucose solution
  • Close monitoring for at least 24 to 48 hours after hypoglycaemic coma

Therapeutic Class

  • Sulfonylureas

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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