Amynil 2 mg (Tablet)
Unit Price: ৳ 12.90 (30's pack: ৳ 387.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Globex pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct treatment for noninsulin dependent diabetes mellitus
- Can be used in combination with metformin
- Can be used in combination with insulin
- May increase potential for hypoglycaemia
Pharmacology
- Decreases blood glucose concentration
- Stimulates insulin release from pancreatic beta cells
- Improves beta cell sensitivity to glucose
- Reduces hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
Dosage
- Initial dose of 1 mg once daily
- Gradual dose titration based on glucose monitoring
- Usual dose range of 1 to 4 mg daily
- Timing and distribution of doses determined by physician
- Consideration for dose adjustment with changes in weight or lifestyle
Administration
- Tablet must be swallowed with sufficient liquid
Interaction
- Interactions with various drugs affecting hypoglycaemic action
- Potentiating drugs include ACE inhibitors, fluconazole, salicylates, etc.
- Attenuating drugs include barbiturates, corticosteroids, etc.
- Interactions with beta-blockers, clonidine, and reserpine
Contraindications
- Not suitable for insulin dependent diabetes mellitus
- Must not be used in diabetic ketoacidosis or diabetic coma
- Contraindicated in patients hypersensitive to glimepiride
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea, vomiting, diarrhea, abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy
- Changeover to insulin necessary during pregnancy
- Must not be taken during breastfeeding
Precautions & Warnings
- Increased risk of hypoglycaemia in initial weeks
- Careful monitoring required
- Immediate intake of carbohydrates for hypoglycaemia
Overdose Effects
- Can produce hypoglycaemia
- Treatment with oral glucose
- Monitoring required for at least 24 to 48 hours
Therapeutic Class
- Sulfonylureas
Storage Conditions
- Store below 30°C
- Keep away from light
- Keep out of reach of children