Comet 500 mg (Tablet)

Unit Price: ৳ 4.02 (10 x 10: ৳ 402.00)
Strip Price: ৳ 40.20

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Square pharmaceuticals plc
Also available as
Comet 850 mg tablet Comet xr 500 mg tablet Comet xr 1000 mg tablet

Title

  • Comet Tablets
  • Metformin Hydrochloride
  • Diabetes Management Medication

Categories

  • Medicine
  • Pharmacology
  • Diabetes Treatment
  • Antihyperglycemic Drug
  • Biguanides

Description

  • Treatment of type 2 diabetes mellitus
  • Oral antidiabetic agent
  • Individualized dosage based on effectiveness and tolerance
  • Management of blood glucose levels
  • Enhancement of insulin sensitivity
  • Reduction of diabetic complications
  • Interaction with other drugs
  • Contraindications and precautions
  • Management of overdose effects
  • Therapeutic class - Biguanides
  • Storage conditions

Color Options

  • White
  • Off-white

Dimensions

  • Various tablet sizes and shapes

Dosage Forms

  • Immediate release tablet
  • Extended release tablet

Dosage Recommendations

  • Dosing for adults and children
  • Initial starting dose
  • Incremental dosage increase
  • Maximum daily dose
  • Administration with meals
  • Recommendations for renal impaired patients

Pharmacological Action

  • Lowering of basal and postprandial plasma glucose
  • Mechanism of action different from sulfonylureas
  • Decrease in hepatic glucose production
  • Improvement of insulin sensitivity
  • Effect on intestinal absorption of glucose

Interaction with Other Drugs

  • Cationic drugs
  • Drugs affecting renal tubular secretion
  • Effects on Cimetidine pharmacokinetics
  • Drugs causing hyperglycemia
  • Potential for drug-induced hypoglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Vitamin B12 absorption decrease
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy and Lactation

  • Risk of congenital abnormalities
  • Avoidance of metformin use during pregnancy
  • Excretion into human breast milk
  • Recommendations for breastfeeding
  • Assessment of potential risk to the child

Precautions and Warnings

  • Excretion by the kidney
  • Risk of hypoglycemia
  • Decreased vitamin B12 level
  • Renal function monitoring
  • Precaution in conditions causing dehydration
  • Interaction with sulphonylurea
  • Interaction with anticoagulants

Use in Special Populations

  • Adjustment based on renal function
  • Effect on growth and puberty
  • Caution in specific age groups
  • Assessment of renal function
  • Recommendations for evaluating GFR

Overdose Effects

  • Absence of hypoglycemia
  • Occurrence of lactic acidosis
  • Medical emergency
  • Hemodialysis for removal

Therapeutic Class

  • Belongs to Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protection from light and moisture
  • Keep out of reach of children

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