Comet XR 1000 mg (Tablet (Extended Release))
Unit Price: ৳ 9.03 (5 x 6: ৳ 270.90)
Strip Price: ৳ 54.18
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Reduction of diabetic complications
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Does not produce hypoglycemia
Dosage & Administration
- Metformin immediate release tablet:
- Individualized dosage
- Starting dose for adults
- Maximum recommended daily doses
- Starting dose for children
- Metformin extended release tablet:
- Swallow whole, do not crush
- Starting dose for adults
- Maximum recommended daily dose for adults
- Not studied in children
- Renal impaired patient precautions
Interaction
- No interaction with Furosemide
- Enhances absorption of Nifedipine
- Potential interaction with cationic drugs
- Minimal effect on Cimetidine pharmacokinetics
- Certain drugs leading to hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Peripheral neuropathy with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities
- Breastfeeding caution due to limited data
Precautions & Warnings
- Excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Therapy cessation before surgery
- Annual estimation of Vitamin B-12 levels
- Interaction with sulphonylurea and anticoagulants
Use in Special Populations
- Dosage adjustment for elderly subjects
- Caution in prescribing to children aged 10-12 years
- Regular renal function assessment
- Caution in renal impairment situations
- Special caution for GFR<30 ml/min
Overdose Effects
- Lactic acidosis as a medical emergency
- Hemodialysis for lactate and Comet XR removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children