Daomin XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- For adults and children from 10 years of age and adolescents
- Monotherapy or in combination with other oral antidiabetic agents or with insulin
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Dosage increases should be made in increments
- Metformin immediate release tablet and extended release tablet options
- Specific dosages for adults, children, and renal impaired patients
Interaction
- Potential interaction with Furosemide and Nifedipine
- Competing for common renal tubular transport systems with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Taste disturbance
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Excretion into human breast milk
- Adverse effects not observed in breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Decreased vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin
- Regular monitoring of renal function
- Adjustment of dosage during concomitant therapy
Use in Special Populations
- Dosage adjustment for elderly subjects based on renal function
- No effect on growth and puberty detected
- Particular caution for children aged between 10 and 12 years
- Renal function assessment before and during treatment
Overdose Effects
- No hypoglycemia seen with doses up to 85 gm
- Lactic acidosis in such circumstances
- Emergency treatment in hospital
- Hemodialysis for removal of lactate and Daomin XR
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of reach of children