D-Fo 850 mg (Tablet)

Unit Price: ৳ 2.50 (30's pack: ৳ 75.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Decent pharma laboratories ltd

Product Title

  • D-Fo Metformin Tablet

Categories

  • Medicine
  • Antidiabetic

Description

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in adults and children
  • Pharmacological action of Metformin
  • Dosage and administration guidelines
  • Interaction with other drugs
  • Contraindications for usage
  • Possible side effects
  • Usage during pregnancy and lactation
  • Precautions and warnings
  • Special considerations for elderly and pediatric use
  • Effects of overdose and emergency treatment
  • Therapeutic class - Biguanides
  • Storage conditions and precautions

Dimensions

  • 3cm x 1cm x 0.2cm

Color Options

  • White

Dosage Form

  • Tablet

Dosage Strength

  • 500mg
  • 850mg

Administration

  • Oral administration
  • With or after meals

Mechanism of Action

  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage Recommendations for Adults

  • Usual starting dose - 500mg twice a day or 850mg once a day
  • Maximum daily dose - 2000mg to 2550mg in divided doses

Dosage Recommendations for Children

  • 500mg twice a day with meal, up to a maximum of 2000mg per day

Extended Release Dosage Form

  • Extended-release tablets
  • Swallow whole, do not crush or chew

Renal Impaired Patient Usage

  • Avoid usage if eGFR below 30 mL/min/1.73 m2

Drug Interaction

  • Interaction with Furosemide and Nifedipine
  • Potential interaction with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure (GFR <30 mL/min)
  • Conditions causing altered renal function

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Gastrointestinal disorders
  • Hepatic function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Excretion into human breast milk
  • No adverse effects in breastfed newborns/infants observed

Precautions & Warnings

  • Risk of D-Fo accumulation and lactic acidosis in renal impairment
  • Lower vitamin B12 level
  • Increased risk of hypoglycemia in combination with insulin
  • Regular monitoring of renal function advised
  • Discontinue 2-3 days before surgery and reinstate after regaining renal function
  • Annual estimation of Vitamin B-12 levels for patients on continuous therapy
  • Caution in concomitant therapy with sulfonylurea

Use in Special Populations

  • Adjusted dosage for elderly based on renal function
  • No effect on growth and puberty detected during controlled studies
  • Particular caution recommended for children aged 10-12 years
  • Renal function assessment before and during treatment

Overdose Effects

  • Hypoglycemia not seen up to 85g doses, lactic acidosis may occur
  • Lactic acidosis is a medical emergency, treated with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C
  • Protected from light and moisture
  • Keep out of the reach of children

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