Diafre 500 mg (Tablet)
Unit Price: ৳ 1.50 (100's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Mystic pharmaceuticals ltd |
| Also available as |
Title and Categories
- Diafre Medicine
- Oral Antidiabetic Drug
- Type 2 Diabetes Management
Indications
- Treatment of type 2 diabetes mellitus in adults and children
- Monotherapy for overweight patients
- Combination therapy with other oral antidiabetic agents or insulin
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage and Administration
- Both immediate release and extended release tablet options
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses for adults and children
- Avoid in renal impaired patients
Interaction
- Minimal effect on certain drugs
- Potential interference with cationic drugs
- Effects on drugs known to produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy and Lactation
- Increased risk of congenital abnormalities and perinatal mortality in uncontrolled diabetes
- Excretion into human breast milk
- Limited data on breastfeeding
Precautions and Warnings
- Excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Need for dose adjustment in certain conditions
- Potential for drug interactions
Use in Special Populations
- Elderly dosage adjustment based on renal function
- Diagnosis confirmation before treatment initiation in pediatric population
- Regular assessment of renal function
- Caution in children aged 10-12 years
Overdose Effects
- Lactic acidosis as a medical emergency
- Hemodialysis for removal of lactate and Diafre
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light and moisture
- Keep out of reach of children