Diafre 500 mg (Tablet)

Unit Price: ৳ 1.50 (100's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Mystic pharmaceuticals ltd
Also available as
Diafre 850 mg tablet

Title and Categories

  • Diafre Medicine
  • Oral Antidiabetic Drug
  • Type 2 Diabetes Management

Indications

  • Treatment of type 2 diabetes mellitus in adults and children
  • Monotherapy for overweight patients
  • Combination therapy with other oral antidiabetic agents or insulin

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage and Administration

  • Both immediate release and extended release tablet options
  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses for adults and children
  • Avoid in renal impaired patients

Interaction

  • Minimal effect on certain drugs
  • Potential interference with cationic drugs
  • Effects on drugs known to produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy and Lactation

  • Increased risk of congenital abnormalities and perinatal mortality in uncontrolled diabetes
  • Excretion into human breast milk
  • Limited data on breastfeeding

Precautions and Warnings

  • Excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Need for dose adjustment in certain conditions
  • Potential for drug interactions

Use in Special Populations

  • Elderly dosage adjustment based on renal function
  • Diagnosis confirmation before treatment initiation in pediatric population
  • Regular assessment of renal function
  • Caution in children aged 10-12 years

Overdose Effects

  • Lactic acidosis as a medical emergency
  • Hemodialysis for removal of lactate and Diafre

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C temperature
  • Protected from light and moisture
  • Keep out of reach of children

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