Diafre 850 mg (Tablet)
Unit Price: ৳ 3.00 (50's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Mystic pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increments for adults
- Dosage increments for children
- Dosage for renal impaired patients
- Immediate release tablet dosage
- Extended release tablet dosage
Interaction
- No chronic co-administration information with Furosemide
- Enhanced absorption with Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy
- Increased risk of congenital abnormalities
- Metformin excretion into breast milk
- No observed adverse effects in breastfed infants
Precautions & Warnings
- Excretion by the kidney
- Risk of lactic acidosis
- Lowered vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Therapy stoppage before clinical investigations
- Dehydration caution
- Annual estimation of Vitamin B-12 levels
- Concomitant therapy with sulphonylurea
- Reduced renal clearance during cimetidine therapy
- Potential interaction with anticoagulants
Use in Special Populations
- Elderly renal function adjustment
- No effect on growth and puberty detected
- Caution in children aged 10-12 years
- Creatinine clearance determination
- Decreased renal function in elderly subjects
- Caution during antihypertensive and NSAID therapy
- Contraindicated in patients with GFR<30 ml/min
Overdose Effects
- Hypoglycemia not seen at high doses
- Occurrence of lactic acidosis
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children