Diamin 850 mg (Tablet)
Unit Price: ৳ 3.00 (30's pack: ৳ 90.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Virgo pharmaceuticals ltd |
| Also available as |
Title
- Diamin
- Metformin Hydrochloride
Category
- Oral Antidiabetic Agent
- Biguanides
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Reduction of diabetic complications in overweight adults
- Monotherapy or combination therapy for adults and children 10 years and older
Pharmacology
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Different dosages for immediate release and extended release tablets
- Dosage adjustments for renal impaired patients
Interaction
- Potential interaction with Furosemide and Nifedipine
- Competition with cationic drugs for renal tubular transport systems
- Possible hyperglycemia with certain drugs
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Use of insulin during pregnancy recommended
- Excretion into breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Excretion by the kidney
- Risk of lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia with insulin
- Monitoring of renal function
- Discontinuation before surgery
- Annual estimation of Vitamin B-12 levels
- Possible interaction with anticoagulants
Use in Special Populations
- Adjusted dosage for elderly based on renal function
- No effect on growth and puberty detected
- Caution in children aged 10-12 years
- Regular monitoring of renal function
- Caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen at high doses
- Occurrence of lactic acidosis
- Hemodialysis for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children