Diamin 850 mg (Tablet)

Unit Price: ৳ 3.00 (30's pack: ৳ 90.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Virgo pharmaceuticals ltd
Also available as
Diamin 500 mg tablet

Title

  • Diamin
  • Metformin Hydrochloride

Category

  • Oral Antidiabetic Agent
  • Biguanides

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Reduction of diabetic complications in overweight adults
  • Monotherapy or combination therapy for adults and children 10 years and older

Pharmacology

  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Different dosages for immediate release and extended release tablets
  • Dosage adjustments for renal impaired patients

Interaction

  • Potential interaction with Furosemide and Nifedipine
  • Competition with cationic drugs for renal tubular transport systems
  • Possible hyperglycemia with certain drugs

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decreased vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities and perinatal mortality
  • Use of insulin during pregnancy recommended
  • Excretion into breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Excretion by the kidney
  • Risk of lactic acidosis
  • Lowering of vitamin B12 levels
  • Increased risk of hypoglycemia with insulin
  • Monitoring of renal function
  • Discontinuation before surgery
  • Annual estimation of Vitamin B-12 levels
  • Possible interaction with anticoagulants

Use in Special Populations

  • Adjusted dosage for elderly based on renal function
  • No effect on growth and puberty detected
  • Caution in children aged 10-12 years
  • Regular monitoring of renal function
  • Caution in situations where renal function may become impaired

Overdose Effects

  • Hypoglycemia not seen at high doses
  • Occurrence of lactic acidosis
  • Hemodialysis for lactic acidosis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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