Formet 500 mg (Tablet)
Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Biopharma limited |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults
- Combination therapy in adults
- Monotherapy for children from 10 years of age and adolescents
- Reduction of diabetic complications
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Recommended starting doses for adults and children
- Guidelines for Metformin immediate release tablet and extended release tablet
- Dosage adjustment for renal impaired patient
Interaction
- No chronic co-administration information with Furosemide
- Nifedipine enhances absorption of Formet
- Interaction with cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Excretion by the kidney
- Risk of accumulation and lactic acidosis with impaired renal function
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia with combination therapy
- Monitoring of renal function
- Therapy stop before surgery and clinical investigations
- Caution in dehydrated or seriously infected patients
- Annual estimation of Vitamin B-12 levels
- Monitoring during concomitant therapy with a sulphonylurea
- Interaction with cimetidine and anticoagulants
Use in Special Populations
- Adjusted metformin dosage for elderly subjects
- Regular assessment of renal function in elderly subjects
- Confirmation of diagnosis before treatment initiation in pediatric population
- No effect on growth and puberty detected during controlled clinical studies
- Monitoring of effect on growth and puberty in metformin-treated children
- Caution in children aged between 10 and 12 years
Overdose Effects
- No hypoglycemia seen with Formet doses up to 85 gm
- Occurrence of lactic acidosis
- Lactic acidosis treatment in hospital
- Effectiveness of hemodialysis in removing lactate and Formet
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children