Glimet 850 mg (Tablet)

Unit Price: ৳ 4.00 (30's pack: ৳ 120.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Millat pharmaceuticals ltd

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Monotherapy
  • Combination therapy
  • Reducing diabetic complications
  • Use in children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Mechanism of action different from sulfonylureas
  • Improves insulin sensitivity
  • Decreases hepatic glucose production

Dosage & Administration

  • Individualized dosage
  • Immediate release tablet
  • Extended release tablet
  • Dosage for adults
  • Dosage for children
  • Dosage adjustments for renal impaired patients

Interaction

  • No chronic interaction information
  • Possible interaction with Furosemide
  • Enhanced absorption with Nifedipine
  • Potential interaction with cationic drugs
  • Drugs causing hyperglycemia
  • Interaction with Cimetidine
  • Potential for hyperglycemia

Contraindications

  • Hypersensitivity
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities
  • Use insulin during pregnancy
  • Excretion into breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of lactic acidosis
  • Lowered vitamin B12 level
  • Increased risk of hypoglycemia
  • Need for renal function monitoring
  • Discontinuation before surgery
  • Effect on vitamin B-12 levels
  • Hypoglycemia risk with sulphonylurea
  • Reduced renal clearance during cimetidine therapy
  • Possible anticoagulant interaction

Use in Special Populations

  • Dosage adjustment for elderly
  • Confirmation of diabetes diagnosis
  • No effect on growth and puberty detected
  • Caution in children aged 10-12 years
  • Creatinine clearance determination
  • Regular monitoring of renal function
  • Caution in situations altering renal function
  • Contraindicated in GFR < 30 ml/min

Overdose Effects

  • No hypoglycemia seen with lower doses
  • Occurrence of lactic acidosis
  • Medical emergency
  • Treatment by hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protected from light and moisture
  • Keep out of reach of children

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