Glucomet 500 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Aristopharma ltd
Also available as
Glucomet 850 mg tablet Glucomet xr 500 mg tablet Glucomet xr 750 mg tablet

Title and Category

  • Glucomet Tablets
  • Oral Antidiabetic Medication
  • Biguanides

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Reduction of diabetic complications
  • Monotherapy or combination therapy
  • Usable for adults, children, and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action compared to sulfonylureas
  • Improves insulin sensitivity
  • Decreases hepatic glucose production

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum daily doses
  • Immediate release and extended release tablet options
  • Gradual dosage increments for tolerance improvement
  • Special dosage considerations for renal impaired patients

Interaction

  • Possible interaction with Furosemide and Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • Impact on drugs causing hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities with uncontrolled diabetes during pregnancy
  • Recommendation to use insulin instead of metformin during pregnancy
  • Excretion of metformin into human breast milk
  • Limited data on adverse effects during breastfeeding

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of metformin accumulation and lactic acidosis with impaired renal function
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia in combination therapy
  • Regular monitoring of renal function
  • Cautious use in elderly and pediatric populations

Use in Special Populations

  • Adjusted dosage based on renal function in elderly subjects
  • Confirmation of type 2 diabetes mellitus diagnosis prior to treatment initiation in children
  • No detected effect on growth and puberty in controlled clinical studies
  • Necessary follow-up on metformin's effect on children's health parameters
  • Regular assessment of renal function

Overdose Effects

  • Hypoglycemia not observed with normal doses
  • Lactic acidosis potential in overdose situations
  • Treatment with hemodialysis in case of lactic acidosis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protect from light and moisture
  • Keep out of the reach of children

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