Glucomet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of overweight patients with inadequate glycaemic control
- Reduction of diabetic complications
- Monotherapy in adults
- Combination therapy in adults
- Combination therapy in children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosing increments
- Dosage for immediate release and extended release tablets
- Dosage for adults and children
- Dosage for renal impaired patients
Interaction
- Interaction with Furosemide and Nifedipine
- Effect on cationic drugs
- Effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Vitamin B12 absorption decrease
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Adverse effects in breastfed newborns/infants
- Limited data on breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of accumulation and lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Therapy suspension before surgery
- Stabilization with insulin in hospital
- Possible interaction with anticoagulants
Use in Special Populations
- Renal function assessment
- Elderly dosage adjustment
- Effect on growth and puberty
- Precaution in children aged between 10 and 12 years
- Creatinine clearance determination
- Caution with renal impairment situations
- Contraindication with GFR < 30 ml/min
Overdose Effects
- Hypoglycemia
- Lactic acidosis
- Emergency treatment in hospital
- Hemodialysis for lactate removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children