Glucomet XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Aristopharma ltd
Also available as
Glucomet 500 mg tablet Glucomet 850 mg tablet Glucomet xr 750 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of overweight patients with inadequate glycaemic control
  • Reduction of diabetic complications
  • Monotherapy in adults
  • Combination therapy in adults
  • Combination therapy in children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosing increments
  • Dosage for immediate release and extended release tablets
  • Dosage for adults and children
  • Dosage for renal impaired patients

Interaction

  • Interaction with Furosemide and Nifedipine
  • Effect on cationic drugs
  • Effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Vitamin B12 absorption decrease
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities and perinatal mortality
  • Recommendation to use insulin during pregnancy
  • Excretion into human breast milk
  • Adverse effects in breastfed newborns/infants
  • Limited data on breastfeeding

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of accumulation and lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Therapy suspension before surgery
  • Stabilization with insulin in hospital
  • Possible interaction with anticoagulants

Use in Special Populations

  • Renal function assessment
  • Elderly dosage adjustment
  • Effect on growth and puberty
  • Precaution in children aged between 10 and 12 years
  • Creatinine clearance determination
  • Caution with renal impairment situations
  • Contraindication with GFR < 30 ml/min

Overdose Effects

  • Hypoglycemia
  • Lactic acidosis
  • Emergency treatment in hospital
  • Hemodialysis for lactate removal

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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