Glucomet XR 750 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Aristopharma ltd |
| Also available as |
Indications for use
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Usage as monotherapy for diabetes management
- Usage in combination with other oral antidiabetic agents or with insulin
Pharmacology
- Belongs to the biguanide type of oral antihyperglycemic drugs
- Lowers both basal and postprandial plasma glucose levels
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage and administration
- Dosage should be individualized based on effectiveness and tolerance
- Dosage should not exceed the maximum recommended daily doses
- Usual starting dose for adults: 500 mg twice a day or 850 mg once a day with meals
- Usual starting dose for children: 500 mg twice a day with meals
- Maximum daily dose for adults: 2000 mg, for children: 2000 mg
- Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks
Interaction
- Potential interaction with Furosemide and Nifedipine
- Possible competition for common renal tubular transport systems with cationic drugs
- No significant effect on Cimetidine pharmacokinetics
- Certain drugs may lead to hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Any type of acute metabolic acidosis
- Severe renal failure
- Acute conditions with the potential to alter renal function
- Acute or chronic diseases that may cause tissue hypoxia
Side effects
- Possible hematologic, metabolic, neurological, gastrointestinal, hepatic, and dermatologic side effects
Pregnancy and lactation
- Use of metformin not recommended during pregnancy, insulin is preferred
- Breastfeeding not recommended due to limited data on adverse effects
Precautions and warnings
- Substantial excretion by the kidney, risk of accumulation and lactic acidosis
- Potential decrease in vitamin B12 levels
- Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
- Regular monitoring of renal function advised
Use in special populations
- Dosage adjustment for elderly individuals based on renal function
- Careful follow-up on the effect of metformin on growth and puberty in children
- Particular caution recommended when prescribing to children aged 10-12 years
Overdose effects
- No hypoglycemia seen with doses up to 85gm
- Lactic acidosis is a medical emergency, must be treated in hospital
- Hemodialysis may be the most effective method for treating lactic acidosis
Therapeutic class
- Belongs to biguanides
Storage conditions
- Keep below 30°C, protected from light and moisture