Glunor 500 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)

Strip Price: ৳ 40.00

Medicine Details

Category	Details
Generic	Metformin hydrochloride
Company	Eskayef pharmaceuticals ltd
Also available as	Glunor 850 mg tablet Glunor xr 500 mg tablet Glunor od 500 mg oros tablet

Product Title and Categories

Glunor - Type 2 Diabetes Medication
Biguanides

Indications

Treatment of type 2 diabetes mellitus
Use in adults and children over 10 years old
Reduction of diabetic complications in overweight patients
Monotherapy or combination therapy with other antidiabetic agents or insulin

Pharmacology

Decreases hepatic glucose production
Decreases intestinal absorption of glucose
Improves insulin sensitivity
Lowers both basal and postprandial plasma glucose

Dosage & Administration

Individualized dosage based on effectiveness and tolerance
Initial dose of 500 mg twice a day for adults
Dosage increases made in increments of 500 mg weekly
Maximum daily dose of 2550 mg for additional glycemic control
Metformin extended release tablet should be swallowed whole

Interaction

Enhanced absorption with Nifedipine
Potential interaction with cationic drugs eliminated by renal tubular secretion
No significant effect on Cimetidine pharmacokinetics
Drugs that may produce hyperglycemia and affect glycemic control

Contraindications

Hypersensitivity to active substance or excipients
Acute metabolic acidosis
Severe renal failure (GFR < 30 mL/min)
Conditions altering renal function or causing tissue hypoxia

Side Effects

Hemolytic anemia
Lactic acidosis
Decrease of vitamin B12 absorption
Peripheral neuropathy
Taste disturbance
Encephalopathy
Gastrointestinal disorders
Liver function test abnormalities
Skin reactions

Pregnancy & Lactation

Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
Excretion into human breast milk
Limited data available for breastfeeding during metformin treatment

Precautions & Warnings

Substantial renal excretion with increased risk of accumulation and lactic acidosis
Lowered vitamin B12 levels
Increased risk of hypoglycemia with insulin
Regular monitoring of renal function
Discontinuation before surgery and reinstatement after renal function is regained
Annual estimation of Vitamin B-12 levels for continuous therapy
Caution during concomitant therapy with a sulphonylurea

Use in Special Populations

Adjustment of metformin dosage in elderly subjects based on renal function
Confirmation of type 2 diabetes mellitus before initiating treatment
No effect on growth and puberty in controlled clinical studies

Overdose Effects

Hypoglycemia not seen with doses up to 85 gm
Occurrence of lactic acidosis in overdose situations
Treatment of lactic acidosis as a medical emergency
Hemodialysis as the most effective method for removing lactate and Glunor

Storage Conditions

Keep below 30°C temperature
Protected from light & moisture
Keep out of the reach of children

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