Glunor 850 mg (Tablet)
Unit Price: ৳ 6.00 (10 x 5: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
Category | Details |
---|---|
Generic | Metformin hydrochloride |
Company | Eskayef pharmaceuticals ltd |
Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Management of type 2 diabetes
- Lowers basal and postprandial plasma glucose
- Different mechanism of action compared to sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
- Increases peripheral glucose uptake and utilization
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Usual starting dose for adults: 500 mg twice a day or 850 mg once a day
- Dosage increases made in increments of 500 mg weekly or 850 mg every 2 weeks
- Maximum daily dose for adults: 2000 mg per day, given in divided doses
- Usual starting dose for children: 500 mg twice a day
- Usual starting dose for Metformin XR in adults: 500 mg once daily with the evening meal
- Dose should be increased in increments of 500 mg weekly
- Maximum dose for Metformin XR in adults: 2000 mg once daily with the evening meal or 1000 mg twice daily
- Metformin extended release tablet should be swallowed whole
- Special precautions for renal impaired patients
Interaction
- No information available about interaction with Furosemide
- Nifedipine may enhance absorption
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Certain drugs may produce hyperglycemia and affect glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic insufciency
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders such as nausea, vomiting, diarrhea, and abdominal pain
- Liver function test abnormalities or hepatitis
- Skin reactions such as erythema, pruritus, urticaria
Pregnancy & Lactation
- Uncontrolled diabetes associated with increased risk of congenital abnormalities and perinatal mortality
- Diabetes during pregnancy should be treated with insulin
- Metformin excreted into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Risk of accumulation and lactic acidosis in patients with impaired renal function
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia when used with insulin or insulin secretagogue
- Regular monitoring of renal function advised
- Therapy should be stopped 2-3 days before surgery
- Glunor not advised in dehydration or serious infections
- Annual estimation of Vitamin B-12 levels recommended
- Monitoring of blood glucose during concomitant therapy with a sulphonylurea
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- No detectable effect of metformin on growth and puberty during controlled clinical studies
- Caution recommended when prescribing to children aged between 10 and 12 years
- Regular assessment of renal function necessary
Overdose Effects
- Hypoglycemia not seen with Glunor doses up to 85 g
- Lactic acidosis a medical emergency, treated in hospital
- Hemodialysis as the most effective method to remove lactate and Glunor
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children
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