Glunor XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (10 x 5: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increments for adults and children
- Usage of immediate release tablet
- Usage of extended release tablet
- Dosage adjustment for renal impaired patient
Interaction
- No chronic interaction with Furosemide
- Enhanced absorption with Nifedipine
- Potential interaction with cationic drugs
- Minimal effect on Cimetidine pharmacokinetics
- Drugs causing hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Risk of hypoglycemia in combination therapy
- Recommendation for annual estimation of Vitamin B-12 levels
Use in Special Populations
- Adjustment of metformin dosage in elderly
- Confirmation of type 2 diabetes mellitus before treatment in children
- No detected effect on growth and puberty
- Special caution for children aged between 10 and 12 years
- Assessment of creatinine clearance
Overdose Effects
- No hypoglycemia seen at high doses
- Occurrence of lactic acidosis
- Emergency treatment in hospital
- Hemodialysis for lactate removal
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children