Glymin 850 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 8: ৳ 200.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children and adolescents
- Reduction of diabetic complications in overweight patients
- Monotherapy for diabetes management
- Combination therapy with other oral antidiabetic agents
- Combination therapy with insulin
- Glycaemic control in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No hypoglycemic effects
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Max daily dose of 2000 mg for adults
- Max daily dose of 2000 mg for children
- Dosage increases in increments of 500 mg
- Extended release tablet option for adults
- Extended release tablet option for children
- Special dosage considerations for renal impaired patients
Interaction
- Enhanced absorption with Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Certain drugs may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy
- Use of insulin recommended during pregnancy
- Excretion into human breast milk
- Breastfeeding not recommended
Precautions & Warnings
- Substantial excretion by the kidney
- Potential for lactic acidosis
- Lowered vitamin B12 levels
- Increased risk of hypoglycemia
- Monitoring of renal function
- Caution in conditions causing dehydration or infection
Use in Special Populations
- Elderly - adjustment based on renal function
- No effect on growth and puberty in controlled studies
- Caution in children aged between 10 and 12 years
- Renal function assessment and monitoring
- Contraindicated in patients with GFR below 30 ml/min
Overdose Effects
- No hypoglycemia seen up to 85 gm dose
- Lactic acidosis as overdose effect
- Medical emergency requiring hospital treatment
- Hemodialysis as effective removal method
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children