Glymin XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (10 x 5: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Title
- Glymin XR
Categories
- Medicine
- Pharmaceutical
Description
- Oral antidiabetic drug for the management of type 2 diabetes mellitus
Dimensions
- N/A
Color Options
- N/A
Functions
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
- Increases peripheral glucose uptake and utilization
Materials
- N/A
Technical Specifications
- Immediate release tablet
- Extended release tablet
Design Elements
- Biguanide type
Usability Features
- Swallow Metformin XR tablet whole and never crush, cut or chew
Dosage
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increases in increments
- Dosage adjustment for renal impaired patients
- Different starting doses for adults and children
- Usage instructions for immediate release and extended release tablets
Interaction
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions & Warnings
- Excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Therapy cessation before surgery and reinstatement after renal function recovery
- Glymin XR therapy not advised in dehydration, serious infections or trauma
- Annual estimation of Vitamin B-12 levels
- Blood glucose monitoring during combined therapy with sulphonylurea
- Interaction with cimetidine and anticoagulants
Use in Special Populations
- Adjusted dosage for elderly subjects based on renal function
- No detected effect on growth and puberty during controlled clinical studies
- Caution in prescribing to children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment and regular monitoring thereafter
- Contraindicated in patients with GFR<30 ml/min
Overdose Effects
- Hypoglycemia not seen with Glymin XR doses up to 85 gm
- Lactic acidosis is a medical emergency
- Treatment with hemodialysis for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Temperature below 30°C
- Protected from light and moisture
- Keep out of the reach of children