G-Metformin 850 mg (Tablet)
Unit Price: ৳ 4.60 (5 x 6: ৳ 138.00)
Strip Price: ৳ 27.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Suitable for overweight patients
- Can be used as monotherapy or in combination with other oral antidiabetic agents or insulin
- Reduced diabetic complications in overweight type 2 diabetic patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Dosage increases in increments
- Immediate release tablet dosage for adults and children
- Extended release tablet dosage for adults
- Caution in renal impaired patients
Interaction
- Potential interaction with Furosemide and Nifedipine
- Competition with cationic drugs for renal tubular transport systems
- Effects on certain drugs leading to hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Hepatic disorders
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis
- Lowered vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin
- Monitoring of renal function
- Caution with surgery and clinical investigations
- Regular assessment of renal function in elderly
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly
- Confirmation of type 2 diabetes mellitus before treatment initiation in children
- Caution in children aged 10-12 years
- Regular assessment of renal function
- Caution with antihypertensive and diuretic therapy
Overdose Effects
- Hypoglycemia not seen up to 85 gm doses
- Lactic acidosis is a medical emergency
- Hemodialysis for removing lactate and metformin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children