Hi-met 850 mg (Tablet)
Unit Price: ৳ 3.00 (100's pack: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Hudson pharmaceuticals ltd |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Effective glycaemic control
- Reducing diabetic complications
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No hypoglycemic effects
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Different dosages for adults and children
- Immediate release and extended release tablet options
- Instructions for renal impaired patients
Interaction
- Possible interaction with Furosemide and Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia and impact glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin during pregnancy
- Excretion of metformin into human breast milk
- Limited data on breastfeeding during metformin treatment
Precautions & Warnings
- Excretion by the kidney
- Risk of lactic acidosis with impaired renal function
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia with certain combinations
- Suggested monitoring of renal function
- Instructions for surgery and clinical investigations
- Annual estimation of Vitamin B-12 levels
- Consideration for concomitant therapy with a sulphonylurea
- Possible interaction with anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- No effect on growth and puberty detected in controlled clinical studies
- Recommendation for careful follow-up in metformin-treated children
- Particular caution in prescribing to children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment and regular assessments
- Special caution in situations where renal function may become impaired
- Contraindication in patients with GFR < 30 ml/min
Overdose Effects
- Lactic acidosis
- Hypoglycemia
- Recommended treatment in hospital
- Hemodialysis for effective removal of lactate and metformin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children