Info-500 500 mg (Tablet)

Unit Price: ৳ 2.00 (50's pack: ৳ 100.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Bristol pharmaceuticals ltd
Also available as
Info 850 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy for adults with diabetes
  • Combination therapy for adults with diabetes
  • Monotherapy for children and adolescents with diabetes
  • Combination therapy for children and adolescents with diabetes
  • Reduction of diabetic complications in overweight patients
  • Improvement of insulin sensitivity

Pharmacology

  • Oral antihyperglycemic drug
  • Management of type 2 diabetes
  • Lowers basal and postprandial plasma glucose levels
  • Different mechanism of action compared to sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity
  • Increases peripheral glucose uptake and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage increments for adult patients
  • Dosage increments for children
  • Use of immediate release tablet
  • Use of extended release tablet
  • Dosage adjustments for renal impaired patients

Interaction

  • Interactions with Furosemide
  • Interactions with Nifedipine
  • Potential interactions with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia
  • Drugs that may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions affecting renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decreased vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy
  • Increased risk of congenital abnormalities
  • Potential effects on breastfeeding

Precautions & Warnings

  • Excretion by the kidney
  • Risk of lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Discontinuation before surgery
  • Annual estimation of Vitamin B-12 levels
  • Monitoring during concomitant therapy with a sulphonylurea
  • Reduced renal clearance during cimetidine therapy
  • Interaction with anticoagulants

Use in Special Populations

  • Adjustment of metformin dosage for elderly subjects
  • Assessment of renal function in elderly subjects
  • Careful follow-up for children treated with metformin
  • Caution in prescribing for children aged 10-12 years
  • Recommendation for renal function assessment before treatment initiation
  • Contraindication in patients with GFR <30 ml/min

Overdose Effects

  • No hypoglycemia at high doses
  • Lactic acidosis as a medical emergency
  • Treatment of lactic acidosis with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C
  • Protect from light & moisture
  • Keep out of the reach of children

Related Brands