Info-850 850 mg (Tablet)
Unit Price: ৳ 3.00 (50's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Bristol pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Starting dose for adults: 500 mg twice a day or 850 mg once a day
- Starting dose for children: 500 mg twice a day
- Dosage increases should be made in increments of 500 mg/weekly or 850 mg/every 2 weeks
Interaction
- Enhancement of absorption with Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Acute metabolic acidosis
- Severe renal failure (GFR <30 mL/min)
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders such as nausea, vomiting, diarrhea
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Metformin excreted into human breast milk
Precautions & Warnings
- Risk of lactic acidosis increases with renal impairment
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
Use in Special Populations
- Elderly: Adjustment of metformin dosage based on renal function
- Pediatric population: Confirmation of type 2 diabetes mellitus before treatment initiation
Overdose Effects
- Lactic acidosis is a medical emergency and must be treated in hospital
- Hemodialysis is the most effective method to remove lactate and metformin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children