Informet 850 mg (Tablet)
Unit Price: ৳ 4.50 (6 x 10: ৳ 270.00)
Strip Price: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults with type 2 diabetes
- Combination therapy for adults with type 2 diabetes
- Use in children aged 10 years and above
- Reduction of diabetic complications in overweight patients
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Usual starting dose for adults
- Dose increases in increments of 500 mg or 850 mg
- Maximum daily dose for glycemic control
- Dosage for children
- Swallowing extended release tablet whole
- Dosage for renal impaired patients
Interaction
- No chronic interaction with Furosemide
- Enhancement of absorption by Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to active substance
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities
- Use of insulin recommended during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions & Warnings
- Excretion by the kidney
- Lowering of vitamin B12 level
- Increase risk of hypoglycemia in combination with insulin
- Regular monitoring of renal function
- Stopping therapy before surgery
- Monitoring of Vitamin B-12 levels
- Possible interaction with anticoagulants
Use in Special Populations
- Dosage adjustment in elderly subjects
- Confirmation of type 2 diabetes before treatment initiation
- Effect on growth and puberty
- Caution in children aged 10-12 years
- Regular assessment of renal function
Overdose Effects
- No hypoglycemia at doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment with hemodialysis
Therapeutic Class
Biguanides
Storage Conditions
- Temperature below 30°C
- Protection from light & moisture
- Keep out of reach of children