Informet LA 500 mg (Long Acting Tablet)
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children and adolescents
- Reduction of diabetic complications in overweight patients
- Monotherapy for type 2 diabetes mellitus
- Combination therapy with other oral antidiabetic agents
- Combination therapy with insulin
- Pharmacological management of type 2 diabetes
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Starting dose of 500 mg twice a day for adults
- Starting dose of 850 mg once a day for adults
- Starting dose of 500 mg twice a day for children
- Maximum daily dose of 2550 mg for additional glycemic control
- Dosage increase in increments of 500 mg weekly or 850 mg every 2 weeks
- Dosage increase made in increments of 500 mg weekly for children
- Usual starting dose of 500 mg once daily with the evening meal for adults (extended release)
- Usual starting dose of 500 mg twice a day for children (extended release)
- Renal impaired patient dosage restrictions
- Swallow extended release tablet whole
Interaction
- No chronic co-administration information with Furosemide
- Enhancement of absorption by Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions with potential to alter renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Hepatic disorders
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin instead of metformin during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis with impaired renal function
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia when used in combination with insulin
- Recommendation for regular monitoring of renal function
- Therapy interruption before surgery and clinical investigations
- Not advised in conditions causing dehydration or in patients suffering from serious infections or trauma
- Recommendation for annual estimation of Vitamin B-12 levels
- Caution with concomitant therapy with a sulphonylurea
- Reduced renal clearance during cimetidine therapy
- Potential interaction with anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- Need for regular assessment of renal function in all diabetics
- Recommendation for confirmation of type 2 diabetes mellitus before treatment in pediatric population
- Recommended cautious prescribing to children aged between 10 and 12 years
- Precautions in situations where renal function may become impaired
- Contraindication in patients with GFR<30 ml/min
Overdose Effects
- No hypoglycemia seen with doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment with hemodialysis for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children