Kemin 850 mg (Tablet)

Unit Price: ৳ 4.01 (50's pack: ৳ 200.50)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Kemiko pharmaceuticals ltd
Also available as
Kemin 500 mg tablet Kemin sr 500 mg tablet

Title

  • Kemin Tablets

Categories

  • Medicine
  • Pharmaceuticals
  • Diabetes Management

Description

  • Oral antidiabetic medication for the treatment of type 2 diabetes mellitus in adults and children
  • Biguanide type drug for managing blood glucose levels in diabetic patients

Dimensions

N/A

Color Options

  • N/A

Functions

  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity
  • Decreases intestinal absorption of glucose
  • Increases peripheral glucose uptake and utilization

Materials

  • Active substance: Metformin hydrochloride
  • Excipients as per formulation

Technical Specifications

  • Immediate Release Tablet:
    • Adult Dosage:
      • 500 mg twice a day
      • 850 mg once a day
      • Increases in 500 mg weekly increments or 850 mg every 2 weeks up to 2000 mg per day in divided doses
    • Children Dosage:
      • 500 mg twice a day
      • Increases in 500 mg weekly increments up to 2000 mg per day in divided doses
    • Renal Impaired Patient: Do not use in patients with eGFR below 30 mL/min/1.73 m²
  • Extended Release Tablet:
    • Adult Dosage:
      • 500 mg once daily with the evening meal
      • Increases in 500 mg weekly increments up to 2000 mg once daily with the evening meal or 1000 mg twice daily with meal
    • Children Dosage: Not studied in children

Design Elements

  • Tablet form

Usability Features

  • Individualized dosage based on effectiveness and tolerance
  • Swallow extended-release tablet whole, do not crush, cut, or chew

Interaction

  • Enhances absorption of Kemin
  • Effects on certain cationic drugs that are eliminated by renal tubular secretion
  • Minimal effects on certain drugs
  • May lead to loss of glycemic control when co-administered with certain drugs

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure (GFR < 30 mL/min)
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decreased vitamin B12 absorption
  • Taste disturbance
  • Gastrointestinal disorders like nausea, vomiting, diarrhea
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Not recommended during pregnancy, insulin is preferred
  • Excreted into human breast milk, breastfeeding not recommended

Precautions & Warnings

  • Substantially excreted by the kidney
  • Lowers vitamin B12 level
  • Increases risk of hypoglycemia in combination with insulin/insulin secretagogue
  • Regular monitoring of renal function
  • Therapy cessation before surgery or clinical investigations
  • Caution in dehydration, serious infections, trauma
  • Annual estimation of Vitamin B-12 levels in continuous therapy
  • Caution in concomitant therapy with a sulphonylurea
  • Renal clearance reduction during cimetidine therapy
  • Possibility of interaction with anticoagulants

Use in Special Populations

  • Elderly: Dosage adjustment based on renal function
  • Pediatric Population:
    • Diagnosis: Confirmation of type 2 diabetes mellitus before treatment initiation
    • Growth and Puberty: No effect detected in controlled clinical studies
    • Renal Function: Regular assessment, especially in situations where renal function may become impaired

Overdose Effects

Lactic acidosis is a medical emergency, hemodialysis for lactate and Kemin removal

Therapeutic Class

  • Biguanides

Storage Conditions

Keep below 30°C, protected from light & moisture, keep out of the reach of children

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