Kemin-SR 500 mg (Tablet)
Unit Price: ৳ 5.00 (50's pack: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for type 2 diabetes in adults
- Combination therapy for type 2 diabetes in adults
- Combination therapy for type 2 diabetes in children and adolescents
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No production of hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose of 500 mg or 850 mg
- Dosage increases in increments of 500 mg or 850 mg
- Maximum daily doses of 2000 mg for adults
- Maximum daily doses of 2000 mg for children
- Renal impairment dosage considerations
- Dosage considerations for extended release tablet
Interaction
- No chronic interaction with Furosemide
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs
- Minimal effect on Cimetidine pharmacokinetics
- Drugs that may lead to loss of glycemic control
- Interaction with thiazides and other diuretics
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbances
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- No observed adverse effects in breastfed newborns/infants
- Limited data on breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia
- Monitoring of renal function
- Discontinuation before surgery
- Not advised in conditions causing dehydration or serious infections
- Annual estimation of Vitamin B-12 levels
- Interaction with sulphonylurea
- Renal clearance reduction during cimetidine therapy
- Possible interaction with anticoagulants
Use in Special Populations
- Adjusted metformin dosage for elderly subjects
- Regular assessment of renal function in elderly
- Confirmation of type 2 diabetes diagnosis before treatment initiation
- No effect on growth and puberty observed during controlled studies
- Caution in prescribing to children aged 10-12 years
- Importance of creatinine clearance determination before treatment
Overdose Effects
- No hypoglycemia seen with doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment of lactic acidosis as a medical emergency
- Hemodialysis for lactate and Kemin-SR removal
Therapeutic Class
- Biguanides
Storage Conditions
- Temperature below 30°C
- Protected from light and moisture
- Keep out of the reach of children