Meglu ER 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- For adults and children from 10 years of age
- Reduction of diabetic complications in overweight patients
- Monotherapy or combination therapy with other oral antidiabetic agents or insulin
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Usual starting dose for adults and children
- Dosage increases made in increments
- Dosage for Metformin immediate release tablet and extended release tablet
- Specific dosage for renal impaired patients
Interaction
- No information available about interaction with Furosemide
- Nifedipine may enhance absorption
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- Effects on Cimetidine pharmacokinetics
- List of drugs that produce hyperglycemia and may impact glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin instead of metformin during pregnancy
- Excretion of metformin into human breast milk
- Limited data on breastfeeding and metformin
Precautions & Warnings
- Substantial renal excretion
- Lowering vitamin B12 levels
- Increased risk of hypoglycemia in combination with insulin
- Recommendation for regular monitoring of renal function
- Caution in dehydration, serious infections or trauma
- Annual estimation of Vitamin B-12 levels
- Adjustment of anticoagulant dosage possible
Use in Special Populations
- Dosage adjustment based on renal function in elderly
- Confirmation of type 2 diabetes mellitus before treatment initiation
- No effect on growth and puberty detected during controlled clinical studies
- Caution when prescribing to children aged between 10 and 12 years
- Regular assessment of renal function
- Special caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen at high doses
- Lactic acidosis is a medical emergency and must be treated in hospital
- Hemodialysis for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children