Met 500 mg (Tablet)
Unit Price: ৳ 4.00 (6 x 10: ৳ 240.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Therapeutic Class
- Biguanides
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
- Does not produce hypoglycemia
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increases in increments
- Usual starting dose for adults and children
- Instructions for immediate release tablet
- Instructions for extended release tablet
- Maximum dose for patients requiring additional glycemic control
- Dosage for renal impaired patients
Interaction
- Interaction with Furosemide and Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may lead to loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Hepatic function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Precautions during pregnancy to reduce risk of malformations
- Excretion into human breast milk
- No observed adverse effects in breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Dosage adjustment based on renal function
- Regular monitoring of renal function
- Recommended discontinuation before surgery
- Caution with dehydration, serious infections, or trauma
Use in Special Populations
- Dosage adjustment for elderly
- No effect on growth and puberty during controlled clinical studies
- Careful follow-up on effect on growth and puberty
- Particular caution in children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment
- Regular renal function assessment
- Caution in situations where renal function may become impaired
- Contraindicated in patients with GFR<30 ml/min
Overdose Effects
- Hypoglycemia not seen with doses up to 85 gm
- Lactic acidosis occurred in such circumstances
- Lactic acidosis is a medical emergency
- Treatment with hemodialysis
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children