Met XR 750 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Opsonin pharma ltd
Also available as
Met 500 mg tablet Met 850 mg tablet Met xr 500 mg tablet Met xr 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Diabetic complications reduction in overweight adult patients
  • Monotherapy or combination therapy for adults
  • Monotherapy or combination therapy for children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Usual starting doses for adults and children
  • Metformin immediate release tablet dosing
  • Metformin extended release tablet dosing
  • Dosage adjustment for renal impaired patients

Interaction

  • No information on interaction with Furosemide
  • Nifedipine may enhance absorption of Met XR
  • Cationic drugs competing for renal tubular transport systems
  • Minimal effects on Cimetidine pharmacokinetics
  • Drugs that tend to produce hyperglycemia
  • Drugs that may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions with potential to alter renal function
  • Conditions causing tissue hypoxia
  • Acute or chronic diseases impacting renal function

Side Effects

  • Blood and lymphatic system disorders
  • Metabolism and nutrition disorders
  • Nervous system disorders
  • Gastrointestinal disorders
  • Hepatobiliary disorders
  • Skin and subcutaneous tissue disorders

Pregnancy & Lactation

  • Uncontrolled diabetes associated risks during pregnancy
  • Insulin recommended for diabetes treatment during pregnancy
  • Metformin excretion into human breast milk
  • Breastfeeding not recommended during metformin treatment

Precautions & Warnings

  • Substantial renal excretion
  • Risk of lactic acidosis with renal impairment
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia in combination therapy
  • Advised for regular renal function monitoring
  • Discontinuation before surgery and reinstatement after renal function control

Use in Special Populations

  • Adjusted dosage for elderly based on renal function
  • Caution in prescribing to children aged between 10 and 12 years
  • Renal function assessment before and during treatment
  • Careful follow-up of metformin effect on growth and puberty in children
  • Contraindicated in patients with GFR < 30 ml/min

Overdose Effects

  • No hypoglycemia seen with Met XR doses up to 85 gm
  • Lactic acidosis occurrence with high doses
  • Lactic acidosis treatment in hospital
  • Hemodialysis for lactic acidosis and Met XR removal

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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