Met XR 750 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Diabetic complications reduction in overweight adult patients
- Monotherapy or combination therapy for adults
- Monotherapy or combination therapy for children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Usual starting doses for adults and children
- Metformin immediate release tablet dosing
- Metformin extended release tablet dosing
- Dosage adjustment for renal impaired patients
Interaction
- No information on interaction with Furosemide
- Nifedipine may enhance absorption of Met XR
- Cationic drugs competing for renal tubular transport systems
- Minimal effects on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
- Drugs that may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions with potential to alter renal function
- Conditions causing tissue hypoxia
- Acute or chronic diseases impacting renal function
Side Effects
- Blood and lymphatic system disorders
- Metabolism and nutrition disorders
- Nervous system disorders
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin and subcutaneous tissue disorders
Pregnancy & Lactation
- Uncontrolled diabetes associated risks during pregnancy
- Insulin recommended for diabetes treatment during pregnancy
- Metformin excretion into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial renal excretion
- Risk of lactic acidosis with renal impairment
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia in combination therapy
- Advised for regular renal function monitoring
- Discontinuation before surgery and reinstatement after renal function control
Use in Special Populations
- Adjusted dosage for elderly based on renal function
- Caution in prescribing to children aged between 10 and 12 years
- Renal function assessment before and during treatment
- Careful follow-up of metformin effect on growth and puberty in children
- Contraindicated in patients with GFR < 30 ml/min
Overdose Effects
- No hypoglycemia seen with Met XR doses up to 85 gm
- Lactic acidosis occurrence with high doses
- Lactic acidosis treatment in hospital
- Hemodialysis for lactic acidosis and Met XR removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children