Metarin 500 mg (Tablet)

Unit Price: ৳ 4.00 (6 x 10: ৳ 240.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Popular pharmaceuticals ltd
Also available as
Metarin 850 mg tablet Metarin xr 500 mg tablet Metarin xr 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • First-line therapy after diet failure
  • Monotherapy in adults
  • Combination therapy in children and adolescents

Pharmacology

  • Oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Immediate release tablet
  • Extended release tablet
  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dose adjustments for renal impaired patients

Interaction

  • Potential interaction with Furosemide and Nifedipine
  • Competing for renal tubular transport systems with certain drugs
  • Effects on drugs causing hyperglycemia

Contraindications

  • Hypersensitivity
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities and perinatal mortality
  • Excretion into breast milk
  • Recommendation of using insulin during pregnancy

Precautions & Warnings

  • Excretion by the kidney
  • Potential for lactic acidosis
  • Lowering vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Caution in dehydration, serious infections, and trauma

Use in Special Populations

  • Adjusted dosage in elderly subjects
  • Confirmation of diabetes mellitus diagnosis before treatment in children
  • No effect on growth and puberty detected
  • Caution in children aged between 10 and 12 years
  • Assessment of renal function

Overdose Effects

  • Occurrence of lactic acidosis in high doses
  • Hypoglycemia not seen up to 85 gm
  • Treatment through hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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