Metarin 850 mg (Tablet)
Unit Price: ৳ 6.00 (6 x 10: ৳ 360.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Can be used in adults as monotherapy
- Can be used in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight patients
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Dosage must be individualized for effectiveness and tolerance
- Maximum recommended daily doses should not be exceeded
- Dosage increases should be made in increments
- Different dosages for adults and children
- Extended release tablet should not be crushed or chewed
- Dosage adjustment for renal impaired patients
Interaction
- Potential interaction with Furosemide
- Enhancement of absorption by Nifedipine
- Potential competition with cationic drugs
- Minimal effects on Cimetidine pharmacokinetics
- Certain drugs may produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Any type of acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic insufficiency
- Acute alcohol intoxication
- Acute or chronic diseases affecting renal function
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes associated with increased risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Limited data available for breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia
- Regular monitoring of renal function advised
- Discontinuation before surgery and reinstatement after renal function regains
- Caution in conditions causing dehydration or serious infections
- Annual estimation of Vitamin B-12 levels for continuous therapy
- Special precautions during concomitant therapy with sulphonylurea
- Possible reduced renal clearance during cimetidine therapy
- Potential interaction with anticoagulants
Use in Special Populations
- Adjustment of dosage based on renal function in elderly subjects
- No effect on growth and puberty detected in controlled clinical studies
- Careful follow-up of effect on growth and puberty recommended
- Particular caution recommended for children aged between 10 and 12 years
- Regular assessment of renal function
- Decreased renal function in elderly subjects
- Special caution in situations where renal function may become impaired
- Contraindicated in patients with GFR<30 ml/min
Overdose Effects
- Hypoglycemia not seen with doses up to 85 gm
- Lactic acidosis occurred in such circumstances
- Lactic acidosis is a medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children