Metfen 850 mg (Tablet)
Unit Price: ৳ 2.50 (50's pack: ৳ 125.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Doctors chemical works ltd |
Indications
- Treatment of type 2 diabetes mellitus
- Management of overweight patients with inadequate glycaemic control
- First-line therapy after diet failure
- Combination therapy with other oral antidiabetic agents or insulin
- Reduction of diabetic complications in overweight patients
- Suitable for adults
- Suitable for children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses should not be exceeded
- Immediate release tablet dosage for adults and children
- Extended release tablet dosage for adults
- Renal impaired patient precautions
- Tablets should be swallowed whole, not crushed, cut, or chewed
Interaction
- No information available about the interaction with Furosemide
- Nifedipine may enhance absorption
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Certain drugs may produce hyperglycemia and affect glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function or causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders such as nausea, vomiting, diarrhea
- Hepatic function test abnormalities or hepatitis
- Skin reactions such as erythema, pruritus, urticaria
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Insulin recommended for diabetes treatment during pregnancy
- Metformin excreted into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Excretion by the kidney, requiring regular monitoring of renal function
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia when used in combination with insulin
- Caution in elderly subjects due to potential decreased renal function
- Special caution in children aged between 10 and 12 years
- Caution in conditions altering renal function or causing dehydration
- Potential interaction with sulphonylureas and anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- Confirmation of type 2 diabetes mellitus diagnosis before treatment initiation
- No effect on growth and puberty detected in controlled clinical studies
- Careful follow-up of effect on growth and puberty recommended in metformin-treated children
- Creatinine clearance assessment before initiating treatment and regularly thereafter
Overdose Effects
- Lactic acidosis is a medical emergency
- Hypoglycemia not seen with doses up to 85 gm
- Hemodialysis for removal of lactate and metformin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children