Metfo 500 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Pacific pharmaceuticals ltd
Also available as
Metfo 850 mg tablet Metfo xr 500 mg tablet Metfo xr 750 mg tablet Metfo xr 1000 mg tablet

Indications

  • Type 2 diabetes mellitus treatment
  • Effective in overweight patients
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents
  • Reduction of diabetic complications in overweight patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial glucose levels
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal glucose absorption
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose for adults: 500mg twice a day
  • Maximum daily dose for adults: 2000mg
  • Usual starting dose for children: 500mg twice a day
  • Maximum daily dose for children: 2000mg
  • Renal impaired patient precautions

Interaction

  • No chronic co-administration information available
  • Enhanced absorption with Nifedipine
  • Potential interaction with cationic drugs
  • No significant effect on Cimetidine pharmacokinetics
  • Drugs causing hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Any type of acute metabolic acidosis
  • Severe renal failure (GFR < 30mL/min)
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Acute or chronic diseases affecting renal function

Side Effects

  • Hemolytic anemia (not known)
  • Lactic acidosis (rare)
  • Vitamin B12 absorption decrease
  • Peripheral neuropathy in vitamin B12 deficiency
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality
  • Uncontrolled diabetes linked to malformations
  • Excretion into breast milk
  • Limited data on breastfeeding effects

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowered vitamin B12 levels
  • Risk of hypoglycemia with insulin
  • Regular monitoring of renal function advised
  • Caution in conditions causing dehydration or infections
  • Monitoring during concomitant therapy with sulfonylurea
  • Reduced renal clearance during cimetidine therapy
  • Potential interaction with anticoagulants

Use in Special Populations

  • Elderly renal function adjustment
  • No effect on growth and puberty detected
  • Caution in children aged 10-12 years
  • Regular renal function assessment
  • Special caution in renal function altering conditions

Overdose Effects

  • Hypoglycemia not seen within specified doses
  • Occurrence of lactic acidosis
  • Treatment with hemodialysis recommended

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protected from light and moisture
  • Keep out of reach of children

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