Metfo 850 mg (Tablet)

Unit Price: ৳ 6.00 (10 x 10: ৳ 600.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Pacific pharmaceuticals ltd
Also available as
Metfo 500 mg tablet Metfo xr 500 mg tablet Metfo xr 750 mg tablet Metfo xr 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Reducing diabetic complications in adults
  • Use in children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Metformin immediate release tablet
  • Metformin extended release tablet
  • Dosage individualized based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage increases in increments

Interaction

  • Co-administration with Furosemide
  • Enhancement of absorption by Nifedipine
  • Potential interaction with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Impact on drugs leading to hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities

Pregnancy & Lactation

  • Uncontrolled diabetes associated with increased risk
  • Recommendation to use insulin during pregnancy
  • Excretion into human breast milk
  • No adverse effects observed in breastfed newborns/infants

Precautions & Warnings

  • Substantially excreted by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Excretion and renal function
  • Therapy interruption before surgery
  • Annual estimation of Vitamin B-12 levels

Use in Special Populations

  • Adjustment of dosage based on renal function
  • No effect on growth and puberty detected
  • Caution in prescribing to children aged 10-12 years
  • Regular assessment of renal function

Overdose Effects

  • Hypoglycemia not seen with doses up to 85 gm
  • Occurrence of lactic acidosis in overdose
  • Treatment of lactic acidosis in hospital
  • Hemodialysis for lactic acidosis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protection from light & moisture
  • Keep out of the reach of children

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