Metfo XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults with type 2 diabetes
- Combination therapy for adults with type 2 diabetes
- Combination therapy for children and adolescents with type 2 diabetes
- Reduction of diabetic complications
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action compared to sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Maximum daily doses should not be exceeded
- Different dosages for immediate release and extended release tablets
- Dosage adjustments based on patient age
- Dosage adjustments for renal impaired patients
Interaction
- Possible interactions with Furosemide and Nifedipine
- Potential interactions with cationic drugs eliminated by renal tubular secretion
- No significant effect on Cimetidine pharmacokinetics
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
- Acute or chronic diseases affecting renal or hepatic function
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Metformin excreted into human breast milk
- Limited data available on breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis with renal impairment
- Lowered vitamin B12 levels
- Increased risk of hypoglycemia when used with insulin
- Regular monitoring of renal function advised
Use in Special Populations
- Required dosage adjustments for elderly subjects
- Monitoring of metformin effect on growth and puberty in children
- Particular caution recommended for children aged 10-12 years
Overdose Effects
- Absence of hypoglycemia at relatively high doses
- Occurrence of lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children