Metin 850 mg (Tablet)
Unit Price: ৳ 4.96 (30's pack: ৳ 148.80)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Supreme pharmaceutical ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for adults
- Combination therapy for children and adolescents
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Immediate release tablet
- Extended release tablet
- Dosage adjustments based on patient age and renal function
Interaction
- No information available about Metin and Furosemide chronic co-administration
- Enhancement of Nifedipine absorption
- Potential interaction with cationic drugs
- Certain drugs may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities
- Metformin excreted into human breast milk
- Limited data available on breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis increases with impaired renal function
- Decreased vitamin B12 levels
- Increased risk of hypoglycemia in combination therapy
- Regular monitoring of renal function advised
- Metin therapy cessation before certain clinical investigations
Use in Special Populations
- Elderly dosage adjustment based on renal function
- No effect on growth and puberty detected in controlled clinical studies
- Special caution in children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment
- Special caution in situations with potential impairment of renal function
Overdose Effects
- No hypoglycemia seen with high doses
- Lactic acidosis is a medical emergency
- Hemodialysis as the most effective method for lactate and Metin removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C
- Protected from light and moisture
- Keep out of the reach of children