Metlife 850 mg (Tablet)
Unit Price: ৳ 4.01 (5 x 10: ৳ 200.50)
Strip Price: ৳ 40.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Silva pharmaceuticals ltd |
| Also available as |
Title
- Metlife Tablet
Categories
- Medicine
- Diabetes Management
Description
- Oral antidiabetic medication for the treatment of type 2 diabetes mellitus
Dosage Forms
- Immediate release tablet
- Extended release tablet
Indications
- Treatment of type 2 diabetes mellitus in adults and children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage Administration
- Usual starting dose of 500 mg
- Maximum daily dose of 2550 mg for adults
- Usual starting dose of 500 mg for children
- Maximum daily dose of 2000 mg for children
- Dosage adjustments based on renal function
- Swallow extended release tablet whole
Interactions
- Potential interactions with Furosemide and Nifedipine
- Competes for renal tubular transport systems with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Effects on drugs causing hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Vitamin B12 absorption decrease
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy Lactation
- Uncontrolled diabetes associated with increased risk of congenital abnormalities and perinatal mortality
- Excreted into human breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions Warnings
- Substantial excretion by the kidney
- Decreased vitamin B12 level
- Risk of hypoglycemia in combination with insulin
- Regular monitoring of renal function
- Therapy stoppage before surgery
- Annual estimation of Vitamin B-12 levels
- Caution with concurrent sulphonylurea therapy
- Potential interaction with anticoagulants
Special Populations
- Elderly – adjustment based on renal function
- Pediatric population – careful follow-up
- Renal function assessment before and during treatment
Overdose Effects
- Hypoglycemia not seen with doses up to 85 gm
- Lactic acidosis is a medical emergency
- Hemodialysis for lactate and Metlife removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children