Metomin 500 mg (Tablet)
Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Somatec pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Used as monotherapy or in combination with other oral antidiabetic agents or with insulin
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Dosage must be individualized based on effectiveness and tolerance
- Usual starting dose for adults is 500 mg twice a day
- Usual starting dose for children is 500 mg twice a day
- Maximum daily dose is 2000 mg, given in divided doses
Interaction
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs
- Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Not recommended during metformin treatment
- Excreted into human breast milk
Precautions & Warnings
- Substantially excreted by the kidney
- Lowering of vitamin B12 level
- Regular monitoring of renal function advised
- Annual estimation of Vitamin B-12 levels recommended
- Interaction with anticoagulants is a possibility
Use in Special Populations
- Dosage adjustment in elderly subjects based on renal function
- No effect on growth and puberty detected
- Particular caution in prescribing to children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment
- Metomin is contraindicated in patients with GFR < 30 ml/min
Overdose Effects
- Lactic acidosis is a medical emergency
- Most effective method to remove lactate and Metomin is hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children