M-Form 850 mg (Tablet)
Unit Price: ৳ 5.50 (100's pack: ৳ 550.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Central pharmaceuticals ltd |
Indications
- Treatment of type 2 diabetes mellitus
- First-line therapy after diet failure for diabetic complications reduction
- Monotherapy for adults
- Combination therapy for adults
- Monotherapy for children from 10 years of age and adolescents
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No hypoglycemia production
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose of 500mg or 850mg
- Dosage increases in increments of 500mg or 850mg
- Maximum daily doses for adults and children
- Extended release tablet instructions
- Dosage adjustments for renal impaired patients
Interaction
- No chronic co-administration information with Furosemide
- Enhanced absorption with Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs causing hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Blood and lymphatic system disorders
- Metabolism and nutrition disorders
- Nervous system disorders
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin and subcutaneous tissue disorders
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Uncontrolled diabetes during pregnancy
- Recommended use of insulin during pregnancy
- Excretion into human breast milk
- Limited data available for breastfeeding
Precautions & Warnings
- Substantially excreted by the kidney
- Increased risk of lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Caution in elderly subjects
Use in Special Populations
- Adjusted dosage for elderly subjects
- Confirmation of type 2 diabetes mellitus before initiation
- No effect on growth and puberty detected
- Caution in prescribing to children aged 10-12 years
- Creatinine clearance determination before treatment
- Renal function assessment before and during treatment
Overdose Effects
- Hypoglycemia with doses up to 85gm not seen
- Occurrence of lactic acidosis in overdose
- Treatment method for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children