M-min 850 mg (Tablet)
Unit Price: ৳ 4.51 (3 x 10: ৳ 135.30)
Strip Price: ৳ 45.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose of 500mg or 850mg
- Dosage increases in increments of 500mg or 850mg
- Maximum daily doses of 2000mg or 2550mg
- Instruction for immediate release tablet and extended release tablet consumption
- Specific dosage advice for children
- Dosage adjustment for renal impaired patients
Interaction
- Interactions with Furosemide and Nifedipine
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- Minimal effect on Cimetidine pharmacokinetics
- List of drugs leading to loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Rare side effects related to blood and lymphatic system disorders
- Very rare side effects related to metabolism and nutrition disorders
- Common and rare nervous system disorders
- Very common gastrointestinal disorders
- Very rare hepatobiliary disorders
- Very rare skin and subcutaneous tissue disorders
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin instead of metformin during pregnancy
- Presence of metformin in human breast milk
- Limited data on adverse effects on breastfed newborns/infants
- Caution and recommendations about breastfeeding during metformin treatment
Precautions & Warnings
- Excretion by the kidney and risk of accumulation and lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia when used in combination with insulin
- Recommendation for regular monitoring of renal function
- Advice to stop therapy before surgery and reinstate after renal function recovery
- Not advised in conditions causing dehydration or serious infections or trauma
- Annual estimation of Vitamin B-12 levels for patients on continuous therapy
- Possible interaction with anticoagulants
Use in Special Populations
- Need for adjusted dosage in elderly subjects based on renal function
- No effect on growth and puberty detected during controlled clinical studies
- Recommended follow-up of metformin effect on growth and puberty in children
- Particular caution recommended when prescribing to children aged between 10 and 12 years
- Regular assessment of renal function before and during treatment
Overdose Effects
- Absence of hypoglycemia at high doses
- Occurrence of lactic acidosis
- Treatment method for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Temperature and protection instructions