Nobesit 500 mg (Tablet)
Unit Price: ৳ 4.00 (4 x 15: ৳ 240.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Type 2 diabetes mellitus treatment
- Control of glycaemic levels
- Monotherapy use
- Combination therapy use
- Treatment in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial glucose levels
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage adjustment based on age
- Immediate release tablet dosing
- Extended release tablet dosing
- Special dosing for renal impaired patients
Interaction
- Co-administration with Furosemide
- Absorption enhancement with Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs causing hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal and tissue function
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy risk
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Excretion into breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Renal function monitoring
- Lowered vitamin B12 levels
- Hypoglycemia risk with insulin combination
- Surgery and clinical investigation considerations
- Dehydration and serious infections avoidance
- Annual estimation of Vitamin B-12 levels
- Possible interaction with anticoagulants
Use in Special Populations
- Dosage adjustment for elderly subjects
- Confirmation of type 2 diabetes diagnosis before treatment
- Effect on growth and puberty not detected in clinical studies
Overdose Effects
- No hypoglycemia with doses up to 85 gm
- Lactic acidosis as medical emergency
- Hemodialysis as most effective removal method
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children