Nobesit 850 mg (Tablet)
Unit Price: ৳ 6.00 (4 x 15: ৳ 360.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title and Categories
- Nobesit Tablets
- Medicine
- Diabetes Management
Indications
- Treatment of type 2 diabetes mellitus
- Adult and pediatric use
- Reduction of diabetic complications
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Improves insulin sensitivity
Dosage & Administration
- Immediate release and extended release tablet options
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage adjustments for adults and children
- Special considerations for renal impaired patients
Interaction
- No chronic interaction with Furosemide
- Enhanced absorption with Nifedipine
- Potential interaction with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia and affect glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Tissue hypoxia related conditions
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Metformin excretion into human breast milk
- Limited data on breastfeeding during metformin treatment
Precautions & Warnings
- Excretion by the kidney and risk of accumulation and lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia in combination with insulin
- Monitoring of renal function
- Dose adjustments for specific conditions or concomitant therapy
Use in Special Populations
- Adjusted dosage for elderly subjects based on renal function
- No effect on growth and puberty in controlled clinical studies
- Special caution for children aged 10 to 12 years
- Recommendations for renal function assessment and monitoring
Overdose Effects
- Hypoglycemia not seen with doses up to 85 gm
- Occurrence of lactic acidosis in overdose
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children