NVmet SR 500 mg (Tablet (Sustained Release))
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Navana pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Diabetic complications reduction
- Monotherapy in adults
- Combination therapy in adults
- Combination therapy in children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Different dosage for immediate release and extended release tablets
- Dosage adjustment for renal impaired patients
Interaction
- Interaction with Furosemide and Nifedipine
- Potential interaction with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Drugs that produce hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- Adverse effects on breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of NVmet SR accumulation and lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia in combination therapy
- Dehydration precautions
- Renal function monitoring
- Renal clearance reduction during cimetidine therapy
- Interaction with anticoagulants
Use in Special Populations
- Metformin dosage adjustment in elderly subjects
- Effect on growth and puberty
- Caution in prescribing to children aged 10-12 years
- Creatinine clearance determination before treatment initiation
- Regular renal function assessment
- Renal function impairment caution
Overdose Effects
- Lactic acidosis in overdose circumstances
- Hypoglycemia with NVmet SR doses up to 85 gm
- Hemodialysis for lactic acidosis treatment
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children