Obid 850 mg (Tablet)

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Delta pharma ltd
Also available as
Obid 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus in overweight patients
  • Can be used as monotherapy or in combination with other oral antidiabetic agents or with insulin
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients
  • Suitable for use in children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose of 500 mg twice a day for adults
  • Dosage increases in increments of 500 mg or 850 mg
  • Maximum daily dose of 2000 mg for adults

Interaction

  • Enhancement of absorption by Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • Minimal effects on Cimetidine pharmacokinetics

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure (GFR < 30 mL/min)
  • Acute conditions altering renal function

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Gastrointestinal disorders such as nausea, vomiting, diarrhea
  • Liver function test abnormalities or hepatitis

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Excretion into human breast milk
  • Adverse effects not observed in breastfed newborns/infants

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowering of vitamin B12 levels
  • Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
  • Regular monitoring of renal function advised

Use in Special Populations

  • Dosing adjustment based on renal function in elderly
  • No effect on growth and puberty in controlled clinical studies
  • Particular caution recommended when prescribing to children aged between 10 and 12 years

Overdose Effects

  • No hypoglycemia observed with doses up to 85 gm
  • Lactic acidosis observed in higher doses
  • Medical emergency requiring hospital treatment

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture

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